Endocrine Abstracts

Background: Hashimoto’s thyroiditis (HT) is the most common autoimmune disorder and, also, the leading cause of hypothyroidism in iodine-sufficient areas. In recent years, a concept emerged, that thyroid autoimmunity could be associated with low-grade chronic inflammation, which may result in future cardiovascular comorbidities, independent of thyroid function. It is therefore essential to diagnose Hashimoto’s thyroiditis as early as possible and to test for thyroid ...

Background: Basal tumor markers are valuable in preoperative evaluation of medullary thyroid carcinoma (Calcitonin and CEA), but are insensitive and nonspecific for papilary thyroid cancer (thyroglobulin). Even if their utility is questionable or not recomended in the evaluation of thyroid nodules, in some cases refered to endocrinology department they are available and can be misleading. We present two cases of thyroid nodules with very high preoperative tumor markers.<p ...

Introduction: Primary adrenal lymphoma is extremely rare. It accounts for <1% of extranodal lymphoma. It affects typically old males with bilateral adrenal gland involvement that leads to adrenal hypofunction. Prognosis is very poor due to the lack of optimum chemotherapeutic regimens.Case Report: A 71 yearr old man with prior history of non insulin dependent diabetes, was admitted to the emergency department with symptoms of progressive weakness, fa...

Introduction: In clinical practice guidelines for differentiated thyroid cancer (DTC) it has been proposed to perform thyroglobulin (Tg) stimulated by rTSH determination 6–12 months after initial therapy in patients with low or intermediate risk, in order to establish the absence of disease. The use of ultrasensitive Tg assays could avoid the need of stimulation to establish the absence of disease.Objectives: To evaluate the usefulness of the determ...

Introduction: Continuous subcutaneous insulin infusion (CSII) represents a treatment option that helps patients with type 1 diabetes (PwT1D) to achieve better glycemic control, reduces hypoglycemia and improves quality of life. In Portugal, the National Health System (SNS) affords CSII treatment to PwT1D, according to certain criteria. Over the years, the number of patients treated with CSII devices supported by SNS has grown exponentially. We analyzed these patient’s pro...

Introduction: In patients with type 1 diabetes (T1D), depression increases the risk for persistent hyperglycemia, diabetes complications and mortality. Most results demonstrated that depression is associated with nearly all important medical and psychosocial outcome parameters of T1D. Also, it has been demonstrated that poor diabetes self-care can result from patients’ lack of knowledge or existing psychosocial issues, primarily depression. The aim of the study was to det...

Introduction: Teriparatide is prescribed for severe osteoporosis based on national protocols. The osteoanabolic drug is followed by an anti-resorbtive medication.Aim: We analyze the treatment sequence options after Teriparatide in patients who finished the 2-year protocol or were early droppers.Material and method: This is a real life study based on Romanian protocol of Teriparatide for severe primary or/and glucocorticoid osteopor...

Bisphenol-A (BPA) has been considered as an endocrine disrupting chemical (EDC) because it can exert estrogenic properties. For bisphenol-S (BPS) and bisphenol-F (BPF) that are BPA analogs and substitutes, their risk to estrogen-dependent cancer has been reported rarely compared with the numerous cases of BPA. In this study, we examined whether BPA, BPS, and BPF can lead to the proliferation, migration, and epithelial mesenchymal transition (EMT) of MCF-7 clonal variant (MCF-7...

Introduction: Pheochromocytomas are rare tumors arising from adrenomedullary chromaffin cells. Pheochromocytomas are a serious clinical condition and undiagnosed cases are associated with increased unexpected cardiovascular mortality.Case report: A female Caucasian patient aged 52-year-old was referred to the endocrine department of a public central hospital because of an incidental right adrenal mass first found 3 years before during the work out of non...

Introduction: Catecholamine secreting tumors are rare neoplasias. About 15% are paragangliomas. If untreated, they are almost invariably lethal. Surgery is the only curative therapy.Case report: A female caucasian patient aged 32 was evaluated in the endocrine department. She had a dramatic medical history: Fallot’s Tetralogy was diagnosed soon after birth but was not corrected. Only a Blalock-Taussing shunt was performed after three isquemic stroke...